Designer Natriuretic Peptides
نویسندگان
چکیده
منابع مشابه
Designer natriuretic peptides for heart failure: advanced in clinical development
Background The increasing burden of heart failure (HF) is a major unmet need for new therapeutics. No new drug has been approved for HF for over a decade. The natriuretic peptides as endogenous activators of particulate guanylyl cyclase (GC) receptors represent an unparalleled opportunity for novel therapeutic agents for HF. Specifically, the GC-A receptor activated by ANP and BNP and GCB activ...
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Renal dysfunction has emerged as an important independent predictor of adverse outcomes, renal as well as cardiovascular. Renal function is crucially affected by intrinsic renal factors (particularly remaining functional renal mass), hemodynamic function (renal perfusion pressure, renal venous pressure), oxygen delivery, and neurohumoral input. The natriuretic peptides play an important role in...
متن کاملNatriuretic peptides.
Natriuretic peptides (NPs) are released from the heart in response to pressure and volume overload. B-type natriuretic peptide (BNP) and N-terminal-proBNP have become important diagnostic tools for assessing patients who present acutely with dyspnea. The NP level reflects a compilation of systolic and diastolic function as well as right ventricular and valvular function. Studies suggest that us...
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Chemistry has generally been associated with inorganic and organic syntheses, metal-organic composites, coordinate metal chemistry, catalyses, block copolymer, coating, thin film, industrial surfactants and small-molecule drug development. That is about to change. Chemistry will also expand to the discovery and fabrication of biological and molecular materials with diverse structures, functiona...
متن کاملNatriuretic peptides and atrial fibrillation.
BACKGROUND AND OBJECTIVE Atrial fibrillation (AF) is the most common arrhythmia in the medical practice, it is associated with an increased total and cardiovascular mortality, as well as cardiovascular morbidity, including stroke and heart failure. AF is encountered in different medical specialties including cardiology, family medicine and emergency medicine as well. Treatment goal is to minimi...
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ژورنال
عنوان ژورنال: Journal of Investigative Medicine
سال: 2009
ISSN: 1081-5589,1708-8267
DOI: 10.2310/jim.0b013e3181946fb2